ObjectiveTo investigate the effects of self-designed tongluo zhitong decoction on lumbar function, pain mediators levels, and inflammatory factors levels in patients with giant lumbar disc herniation (LDH) under the guidance of collateral disease theory. Methods127 patients with giant LDH admitted to Zhengzhou orthopaedics hospital were selected as the research objects, and they were divided into control group (63 cases) and observation group (64 cases) by the random number method. Patients in the control group received pingle massage tendon therapy, while the patients in the observation group were treated with self-designed tongluo zhitong decoction based on the control group. After 6 weeks of treatment, the clinical efficacy, and adverse reactions of the two groups were compared. The lumbar function, serum pain mediators levels and serum inflammatory factors levels were detected and compared between the two groups before treatment and 6 weeks after treatment. ResultsWith 6 weeks of treatment, the total effective rate of treatment of the observation group (87.50%) was significantly higher than that of the control group (69.84%), with a statistically significant difference (P＜0.05). After 6 weeks of treatment, the Oswestry Disability Index (ODI) scores decreased significantly, and the Japanese Orthopaedic Association (JOA) scores increased significantly in both groups. The observation group reached lower ODI score and higher JOA score as compared with the control group, with statistically significant differences (P＜0.05). The levels of serum β-endorphin (β-EP) increased significantly in the patients of both groups, while the levels of prostaglandin E2 (PGE2) and 5-hydroxytryptamine (5-HT) significantly decreased. The observation group reached higher level of β-EP, and lower levels of PGE2 and 5-HT as compared with the control group, with statistically significant differences (P＜0.05). The levels of interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) in the two groups decreased significantly, and the levels of IL-6, CRP and TNF-α in the observation group were significantly lower than those in the control group, with statistically significant differences (P＜0.05). ConclusionUnder the guidance of collateral disease theory, self-designed tongluo zhitong decoction has a definite clinical effect on the treatment of patients with giant lumbar disc herniation, which can effectively regulate the levels of pain mediators, reduce the levels of inflammatory factors, and improve lumbar function of patients without obvious adverse reactions, and it is worthy of clinical application.

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