ObjectiveTo explore the relationship between partial deletion of AZFc and spermatogenesis dysfunction in male infertility patients in Guangxi. MethodsA total of 268 infertile male patients in Guangxi, who admitted to our hospital from June 2018 to September 2021, were selected as the research objects and divided into azoospermia group (88 cases), severe oligospermia group (103 cases), and oligospermia group (77 cases) according to the results of semen examination. According to the age of infertile patients, 100 cases with normal physical examination during the same period were selected as the control group. AZFc deletion and DAZ gene copy number of research objects in two groups were detected and analyzed. ResultsAmong 268 cases of infertility, there were 78 cases with partial AZFc deletion, and the deletion rate was 29.10%. The AZFc deletion rate was 3.00% in the control group with normal physical examination. The AZFc deletion rate was significantly higher in the azoospermia group than that in the oligospermia group and control group, and it was significantly higher in severe oligospermia group than in the control group, with statistically significant differences (P＜0.05). The detection and analysis of STS sequence sites detection in 268 patients showed that among the 6 sequence tag sites, the AZFc deletion rate of SY254 sequence site was the highest at 34.70%, that of SY1125 sequence site was the second at 23.13%, and that of SY160 sequence site was the third at 16.42%. The analysis of DAZ gene copy deletion in 81 cases with AZFc partial deletion (78 infertility patients, 3 cases with normal physical examination) showed that there were 30 cases with DAZ1/2 copy deletion, 55 cases with DAZ3/4 copy deletion, and some infertile patients had DAZ1/2 and DAZ3/4 co-deletion. There were no statistically significant differences in the DAZ1/2 gene copy deletion rate among the azoospermia group, severe oligospermia group, oligospermia group and control group (P＞0.05). However, there were statistically significant differences in DAZ3/4 copy deletion rate among the four groups (P＜0.05). The DAZ3/4 copy deletion rate in azoospermia group, severe oligospermia group and oligospermia group was significantly higher than that in normal control group (P＜0.05). ConclusionThe higher the rate of AZFc deletion is, the more severe spermatogenesis dysfunction is in male infertility patients in Guangxi. However, partial deletion of AZFc does not lead to absolute infertility. Early detection of AZFc deletion is helpful to guide the treatment of patients and is of great significance to eugenics.

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