ObjectiveTo explore the effects of different concentrations of Corydalis saxicola Bunting total alkaloids (CSBTA) on the Porphyromonas gingivalis(P.gingivalis) in vitro growth. MethodsThe minimum inhibitory concentration(MIC) and the minimum bactericidal concentration(MBC) of CSBTA against P.gingivalis were determined. P.gingivalis was treated with different concentrations(0.01 g/L, 0.02 g/L, 0.04 g/L, 0.08 g/L, 0.16 g/L, 0.32 g/L) of CSBTA solutions to detect their relative growth inhibitory rates against P.gingivalis. P.gingivalis was treated by 1/4 MIC, 1/2 MIC, and MIC of CSBTA solutions to observe and detect their impacts on the growth of P.gingivalis, and the growth curve was drawn.ResultsThe MIC of CSBTA against P.gingivalis was 0.08 g/L, and the MBC was 0.16 g/L. It inhibited over 50% of bacteria′s growth when the concentration of CSBTA reached 0.02 g/L(the relative growth inhibitory rate was ［55.36±7.39］%) and over 90% of bacteria′s growth when the concentration of CSBTA reached 0.08 g/L (the relative growth inhibitory rate was ［93.21±3.38］%). The 0.02 g/L, 0.04 g/L, and 0.08 g/L CSBTA solutions inhibited the growth of P.gingivalis to varying degrees, and the inhibition showed concentration dependence. Therefore，P.gingivalis grew slowly when treated with the 0.02 g/L or 0.04 g/L CSBTA solution, while its′ growth was almost completely inhibited when treated with the 0.08 g/L CSBTA solution. ConclusionCSBTA had a relevantly strong inhibitory effect on the growth of P.gingivalis in vitro.

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