内科

目的探讨人群呼吸道感染与其家人家庭内吸烟的关系。方法根据家人在家庭内的吸烟情况，将316名健康体检成年人分为严格控烟组、部分控烟组与未控烟组。比较3组研究对象的外周血白细胞介素-1（IL-1）、免疫球蛋白G、淋巴细胞计数、超敏C反应蛋白、肿瘤坏死因子α和中段晨尿可替宁水平，以及3组研究对象的呼吸道感染情况（随访1年）；对研究对象中段晨尿可替宁水平与其他生化指标水平的关系进行相关分析。结果在接受调查的316名研究对象中，家庭严格控烟者有92名（严格控烟组），家庭部分控烟者有103名（部分控烟组），家庭未控烟者有121名（未控烟组）。外周血IL-1、免疫球蛋白G水平和淋巴细胞计数均呈严格控烟组＞部分控烟组＞未控烟组,而外周血超敏C反应蛋白、肿瘤坏死因子α和中段晨尿可替宁水平均呈严格控烟组＜部分控烟组＜未控烟组（均P＜0.05）。严格控烟组研究对象的呼吸道感染发生率（22.83%）低于部分控烟组（36.89%）与未控烟组（42.98%）（均P＜0.05）；部分控烟组与未控烟组研究对象的呼吸道感染发生率比较，差异无统计学意义（P＞0.05）。研究对象中段晨尿的可替宁水平与其外周血IL-1、免疫球蛋白G水平与淋巴细胞计数呈负相关，与其外周血超敏C反应蛋白、肿瘤坏死因子α水平呈正相关。结论人群呼吸道感染与其家人家庭内吸烟关系密切，严格控烟对提高家庭成员的机体免疫力、降低呼吸道感染发生率具有重要意义。

ObjectiveTo explore the relationship between people′s respiratory tract infection and their family members in-home smoking. MethodsAccording to the in-home smoking condition of their family members, 316 healthy adult examinees were divided into a strict tobacco control group, a partial tobacco control group, or a no tobacco control group. The following indices were compared among the three groups of research objects, including peripheral blood interleukin-1(IL-1), immunoglobulin G, lymphocytes counts, hypersensitive C reactive protein, and tumor necrosis factor-α levels and the morning midstream urinary cotinine level, as well as the condition of respiratory tract infection within the one-year follow-up. A correlation analysis was performed on the relationships of the morning midstream urinary cotinine level with the other biochemical indices levels. ResultsAmong the 316 research objects being investigated, 92 were in family with strictly family controlled (strict tobacco control group), 103 were in family with partially family controlled (partial tobacco control group), and 121 were in family with no family controlled (no tobacco control group). The peripheral blood IL-1 and immunoglobulin G levels and lymphocytes counts decreased in the sequence of the strict tobacco control group, the partial tobacco control group, and the no tobacco control group; but the peripheral blood hypersensitive C reactive protein and tumor necrosis factor-α and morning midstream urinary cotinine levels increased in the sequence of the strict tobacco control group, the partial tobacco control group, and the no tobacco control group(all P＜0.05). The incidence of respiratory tract infection of the strict tobacco control group (22.3%) was lower than that of the partial tobacco control group (36.89%) and the no tobacco control group (42.98%)(all P＜0.05), but no statistically significant difference was observed in the incidence of respiratory tract infection between the partial tobacco control group and the no tobacco control group (P＞0.05). Research objects′ morning midstream urinary cotinine level was negatively related to the peripheral blood IL-1 and immunoglobulin G levels and the lymphocytes counts but positively related to the peripheral blood hypersensitive C reactive protein and tumor necrosis factor-α levels. ConclusionPeople′s respiratory tract infection is closely related to their family members in-home smoking, and strict tobacco control is of great impact for their family members on improving the body′s immunity and reducing the incidence of respiratory tract infection.