ObjectiveTo investigate the relationship between the levels of serum hepatocyte growth factor (HGF) and prealbumin (PAB) and the severity of illness and prognosis in children with severe mycoplasma pneumoniae pneumonia (SMPP). MethodsA total of 102 children with SMPP were selected and divided into non-critical group (n=35), critical group (n=31), and extremely critical group (n=36) according to the simplified Pediatric Critical Illness Score. According to the prognosis after 28 days of treatment, the children were divided into poor prognosis group (n=26) and good prognosis group (n=76). The clinical data and laboratory parameters of all children were collected. The levels of serum HGF and PAB in SMPP children with different severity of illness were compared. Multivariate logistic regression analysis was used to analyze the influencing factors of poor prognosis in SMPP children , and receiver operating characteristic (ROC) curve was used to evaluate the predictive value of serum HGF and PAB levels for poor prognosis in SMPP children. ResultsThe serum HGF level increased and the serum PAB level decreased successively in the non-critical group, the critical group and the extremely critical group (all P＜0.05). The results of multivariate logistic regression analysis showed that the elevated serum HGF level was an independent risk factor and the elevated serum PAB level was an independent protective factor for poor prognosis in SMPP children (all P＜0.05). The ROC curve showed that the area under the curve of the combined serum HGF and PAB levels was greater than that of the two indicators alone in predicting poor prognosis in SMPP children (all P＜0.05). ConclusionSerum HGF and PAB levels are related to the severity of illness and prognosis in SMPP children, and they can be used as predictive indicators of prognosis in SMPP children.

无