ObjectiveTo investigate the clinical effect of donepezil combined with computerized cognitive remediation therapy (CCRT) in the treatment of patients with mild to moderate Alzheimer′s disease (AD). MethodsA total of 110 patients with mild to moderate AD were selected as research objects, and they were randomly divided into observation group (55 cases) and control group (55 cases). The control group was given donepezil hydrochloride tablets based on the symptomatic treatment, while the observation group was given CCRT based on the control group. Before and after treatment, the Wechsler Adult Intelligence Scale-Revised Chinese (WAIS-RC), Wisconsin Card Sorting Test (WCST), Barthel index (BI) scale, World Health Organization Quality of Life-BREF (WHOQOL-BREF) were used to evaluate patients′ intelligence quotient, cognitive function level, self-care ability, life quality, respectively. ResultsSix months after treatment, the verbal intelligence quotient, operational intelligence quotient, and total intelligence quotient scores in WAIS-RC and the WMS-RC score in the observation group were higher than those in the control group; the WCST test results in the observation group were superior to those in the control group; the BI scale score in the observation group was higher than that in the control group, and the WHOQOL-BREF scores in the physiological, psychological, social relationship, and environmental domains were higher in the observation group than in the control group(all P＜0.05). ConclusionDonepezil combined with CRRT can help improve cognitive function, self-care ability and life quality in patients with mild to moderate AD.

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