ObjectiveTo compare the differences of clinical and histopathologic features between ischemic colitis and ulcerative colitis, which can provide the basis for the diagnosis and helpful for treatment. MethodsClinical data of 20 cases patients with ischemic colitis (IC) and 30 cases patients with ulcerative colitis (UC) from 2010 to 2014 in the First Affiliated Hospital of Guangxi Medical University were retrospective analyzed, the differences of gender, age, course of disease, disease history, clinical manifestation, colonoscopy findings, and pathological feature of the two groups were compared. ResultThe patients with IC was more prevalent in people over 60 years old, rapid onset, short duration and often associated with hypertension, diabetes and other basic diseases, while patients with UC mainly in young people, long course of disease, with the basis of disease was rare;The clinical manifestations of IC mainly abdominal distension and vomiting, While mucous bloody stool and tenesmus were more common in patients with UC. Under colonoscopy, IC endoscopic lesions less involved rectum, often appear mucosal edema, a longitudinal ulcer. UC was often implicates rectum, accompanied with inflammatory pseudo-polyps, ulcer showed a map like, pathological changes were continuously. In pathological aspects, vascular dilatation and congestion, interstitial edema and vessel wall thickening were usually presented in IC, the inflammatory cell infiltration and crypt abscess was rare in IC. ConclusionIntegrated analysis of age, previous medical history, clinical symptoms and endoscopic, histopathological examination findings would be helpful for differential diagnosis of IC and UC.

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