内科

目的探讨颅内血管狭窄与超敏C反应蛋白（hs-CRP）及D-二聚体水平的相关性。方法选取2011年8月至2013年7月在我院住院并行头颅GE-MRA检查的120例患者，根据有无脑血管狭窄将患者分为观察组（脑血管狭窄组）60例（又分轻、中、重度狭窄）及对照组（脑血管正常组）60例，对两组患者行hs-CRP及D-二聚体水平的测定并比较分析血浆hs-CRP、D-二聚体、年龄、性别、高血压、糖尿病、血脂、吸烟史等因素与脑血管狭窄的相关性。结果观察组患者hs-CRP明显高于对照组（P＜0.01），两组患者D-二聚体水平没有统计学差异（P＞0.05）。轻、中、重度脑血管患者的hs-CRP及D-二聚体水平无统计学差异。多元回归分析显示吸烟，高血压，高hs-CRP水平与脑血管狭窄密切相关。结论吸烟，高血压，hs-CRP升高是脑血管狭窄的危险因素，吸烟与脑血管狭窄高度相关。应及时干预危险因素，避免脑梗死发生。

ObjectiveTo investigate the correlation of the hypersensitive c-reactive protein (hs-CRP) and D-dimer with cerebrovascular stenosis. Methods120 patients who had underwent brain GE-MRA examination in our hospital from August 2011 to July 2011 were selected, and were divided into observation group (the cerebrovascular stenosis group) and control group (the normal group), with 60 cases in each, according to the presence or absence of cerebrovascular stenosis. The correlation analysis was made between the levels of the hs-CRP, D-dimer, age, gender, hypertension, diabetes, blood lipids, smoking history, etc and cerebrovascular stenosis. ResultsThe levels of hs-CRP in the observation group were higher than that in the control group (P＜0.01), but there was no significant difference in D-dimer between the two groups (P＞0.05). Based on multiple regression analysis, the increased levels of hs-CRP, hypertension, smoking history were all closely related with cerebrovascular stenosis. Besides smoking, high blood pressure, high hs-CRP levels were also closely related to cerebrovascular stenosis. ConclusionsSmoking, hypertension, increased levels of hs-CRP are all risk factors for cerebrovascular stenosis, and smoking is highly correlated with cerebrovascular stenosis. Risk factors should be timely intervention to avoid the occurrence of cerebral infarction.