内科

目的探讨血清降钙素原（PCT）水平检测在腹腔感染诊断和治疗中的临床意义。方法选择腹腔感染患者72例作为观察组，并根据患者感染的严重程度分为普通感染组和严重感染组；选取同期在我院体检中心体检的健康人群40例为对照组。比较两组患者及健康人群APACHE-Ⅱ评分及血清PCT水平的差异以及观察组患者治疗前后血清PCT的变化。结果严重感染组患者血清PCT水平及APACHE-Ⅱ评分明显高于普通感染组患者和对照组；普通感染组患者血清PCT水平及APACHE-Ⅱ评分明显高于对照组。Pearson相关性分析结果显示，腹腔感染患者血清PCT水平及APACHE-Ⅱ评分随患者感染严重程度的增加而升高。严重感染组与普通感染组患者治疗后PCT水平显著降低，与治疗前比较差异均有统计学意义（P＜0.05）；但两感染组患者治疗后的血清PCT水平仍显著高于对照组，差异有统计学意义（P＜0.05）。结论患者血清PCT水平与腹腔感染的严重程度密切相关，可用于判断患者感染的严重程度及治疗效果，对治疗具有指导作用。

ObjectiveTo study the clinical significance of detecting the serum levels of PCT in patients with abdominal infection. Methods72 patients defined as abdominal infection (observation group) were enrolled and assigned into general and severe infection groups according to the severity of the infection, and 40 healthy volunteers(control group )were selected from medical examination center. The serum levels of PCT and APACHE- Ⅱ score in observation group and control group were detected and compared. The serum levels of PCT in observation group before and after treatment were also compared. ResultsThe serum levels of PCT and APACHE- Ⅱ score in severe infection group were significantly higher than those in the control group and general infection group, the serum levels of PCT and APACHE- Ⅱ score in general infection group were significantly higher than those in the control group. The pearson correlation analysis showed that the serum levels of PCT and APACHE- Ⅱ score were increased with the severity of infection. After treatment, the serum levels of PCT in the general and severe infection groups were significantly decreased compared with before treatment, but were significantly higher than those in the control group(P＜0.05). ConclusionsThe serum levels of PCT are closely related to the severity of infection, and may be used as index for the estimation of the severity of the infection and the effect of treatment.