Research on the influencing factors of carotid intima-media thickening and the predictive value of the triglyceride-glucose index for carotid intima-media thickening in patients with hypertension and type 2 diabetes mellitus
ObjectiveTo analyze the influencing factors of carotid intima-media thickness (CIMT) thickening in patients with hypertension and type 2 diabetes mellitus (T2DM), and to explore the value of triglyceride-glucose (TyG) index in evaluating CIMT thickening. MethodsA total of 209 patients with hypertension and T2DM were selected as research subjects, and their general clinical data and results of laboratory tests and carotid artery color Doppler ultrasound tests were collected. According to whether they had CIMT thickening or not, the patients were divided into a CIMT thickening group (n=111) or a CIMT non-thickening group (n=98). The clinical data of the two groups were compared, among which the factors affecting CIMT thickening were analyzed by binary classification multivariate logistic regression, and the receiver operating characteristic (ROC) curve of the TyG index in evaluating CIMT thickening was drawn. ResultsThere were statistically significant differences in gender, age, T2DM course, high-density lipoprotein-cholesterol (HDL-C) level, fasting blood glucose level, hemoglobin A1c, and TyG index between the two groups (all P<0.05). Male, aging, and high TyG index were risk factors for CIMT thickening in patients with hypertension and T2DM, and an elevated HDL-C level was a protective factor for their CIMT thickening (all P<0.05). The area under the ROC curve of the TyG index in evaluating CIMT thickening was 0.606 and the optimal cut-off value was 7.7 (the sensitivity was 39.81%, the specificity was 83.16%, and the Youden index was 0.230). ConclusionMale, aging, and high TyG index are risk factors, and an elevated HDL-C level is a protective factor for CIMT thickening in patients with hypertension and T2DM. The TyG index has a certain value in evaluating CIMT thickening in patients with hypertension and T2DM.