ObjectiveTo explore the effect of levetiracetam combined with oxcarbazepine in the treatment of children with epilepsy. MethodsA total of 80 children with epilepsy were selected and divided into a control group or an observation group by using the random number table method, with 40 cases in each group. The control group was treated with oxcarbazepine, based on which the observation group was treated with levetiracetam additionally. Both groups were treated for 16 weeks. The therapeutic effect, improvement of epileptiform discharge on electroencephalogram, and serum nerve injury factors (glial fibrillary acidic protein ［GFAP］, S-100β) before and after treatment, as well as the occurrence of adverse reactions during treatment, were compared between the two groups. ResultsThe total effective rate of treatment and overall improvement rate of electroencephalogram in the observation group were higher than those in the control group (all P＜0.05). Before treatment, there was no statistically significant difference in serum GFAP or S-100β level between the two groups (all P＞0.05). After 16 weeks of treatment, the serum GFAP and S-100β levels of the observation group were lower than those of the control group (all P＜0.05). There was no statistically significant difference in the incidence of adverse reactions during treatment between the two groups (P＞0.05). ConclusionThe combination of levetiracetam and oxcarbazepine has a significant effect in the treatment of children with epilepsy, which can effectively reduce the occurrence of epileptiform discharge on electroencephalogram and protect the neurological function and is safe and reliable.

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