内科

目的研究榄香烯注射液联合TP化疗同步放疗治疗局部晚期食管癌患者的效果和安全性。方法选取116例局部晚期食管癌患者为研究对象，并将其随机分为对照组、联合组，每组58例。对照组采用TP化疗同步放疗治疗，联合组在对照组基础上加用榄香烯注射液治疗，两组均治疗3个周期。比较两组治疗3个周期后疗效，治疗前和治疗3个周期后卡氏体能状态量表（KPS）评分、血清肿瘤标志物［癌胚抗原、糖类抗原125、糖类抗原199、鳞状细胞癌抗原（SCCA）］水平、血清微小RNA（miRNA）-623、miRNA-483-5p相对表达水平和治疗期间不良反应发生情况。结果治疗3个周期后，联合组客观缓解率（81.03%）高于对照组（62.07%），KPS评分和血清miRNA-623相对表达水平高于对照组，血清癌胚抗原、糖类抗原125、糖类抗原199、SCCA水平和miRNA-483-5p相对表达水平均低于对照组（均P＜0.05）。治疗期间，两组放射性肺炎、肝损伤发生率差异均无统计学意义（均P＞0.05）；但联合组放射性食管炎、血小板下降、白细胞降低发生率均低于对照组（均P＜0.05）。结论采用榄香烯注射液联合TP化疗同步放疗治疗局部晚期食管癌患者可获得更好的临床疗效，减少不良反应的发生，提高体能状态。

ObjectiveTo study the effect and safety of elemene injection combined with concurrent TP chemotherapy and radiotherapy in the treatment of patients with locally advanced esophageal cancer. MethodsA total of 116 patients with locally advanced esophageal cancer were selected as research subjects, and they were randomly divided into a control group or a combination group, with 58 cases in each group. The control group was treated with concurrent TP chemotherapy and radiotherapy, based on which the combination group was treated with elemene injection additionally, and both groups were treated for 3 cycles. The efficacy after 3 cycles of treatment, the Karnofsky Performance Scale (KPS) score, serum tumor markers (carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199, squamous cell carcinoma antigen ［SCCA］) levels, and serum relative expression levels of microRNA (miRNA)-623 and miRNA-483-5p before and after 3 cycles of treatment, as well as the occurrence of adverse reactions during treatment, were compared between the two groups. ResultsAfter 3 cycles of treatment, the objective response rate of the combination group (81.03%) was higher than that of the control group (62.07%), the KPS score and serum relative expression level of miRNA-623 were higher than those of the control group, and the serum levels of carcinoembryonic antigen, carbohydrate antigen 125, carbohydrate antigen 199, and SCCA and relative expression level of miRNA-483-5p were lower than those of the control group (all P＜0.05). During treatment, there was no statistically significant difference in the incidence of radiation pneumonitis or liver injury between the two groups (all P＞0.05), while the incidences of radiation esophagitis, thrombocytopenia and leukopenia in the combination group were lower than those in the control group (all P＜0.05). ConclusionThe application of elemene injection combined with concurrent TP chemotherapy and radiotherapy in the treatment of patients with locally advanced esophageal cancer can achieve better clinical efficacy, reduce the occurrence of adverse reactions, and improve physical status.