内科

目的探讨慢性脑供血不足（CCCI）致非痴呆型血管认知功能障碍的危险因素。方法将120例CCCI患者根据临床痴呆评定量表（CDR）分为非痴呆性血管性认知功能障碍组（VCIND组，52例）及非VCIND组（68例），建立logistic回归模型，分析CCCI患者高血压、糖尿病、高脂血症、脑梗死等各种危险因素与VCIND的关系。结果单因素分析结果显示糖尿病、脑梗死的多次发作及多部位发生及低教育程度与CCCI致VCIND有关；多因素分析证实糖尿病、脑梗死的多次发作及多部位发生及低教育程度与CCCI致VCIND有关，OR值分别为13.255、12.862、9.051、1.486（P＜0.01）。结论糖尿病、脑梗死的多次发作及多部位发生、低教育程度与CCCI致VCIND有关，可能是CCCI致VCIND的独立危险因素。

ObjectiveTo evaluate the risk factors of vascular cognitive impairment without dementia(VCIND) induced by CCCI. Methods120 patients with CCCI were divided into VCIND group (n=52) and control group (n=68) by the clinical dementia ratio scale (CDR). The relationship between VCIND and each risk factor (hypertension, diabetes mellitus, hyperlipidemia cerebral infarction ) was analyzed by logistic-regression models. ResultsUnivariate analysis showed that diabetes mellitus, multiple sites and multiple episodes of cerebral infarction, low educational attainment were significantly associated with the vascular cognitive impairment induced by CCCI; logistic regression analysis indicated that diabetes mellitus(OR=13.255), multiple sites(OR=12.862) and multiple episodes(OR=9.051) of cerebral infarction, low educational attainment(OR=1.486) were the independent risk factors(P＜0.05). ConclusionsDiabetes mellitus, multiple sites and multiple episodes of cerebral infarction, low educational attainment are associated with VCIND, and they may be the independent risk factors of VCIND induced byCCCI.

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