ObjectiveTo investigate the effect of valsartan combined with enalapril on cardiac function and BNP level in patients with chronic heart failure. Methods 90 hospitalized patients with chronic heart failure were selected and randomly divided into observation group and control group with 45 cases in each. Low-salt diet, oxygen, ECG monitor, cardiac, diuretic, and angiotensin converting enzyme inhibitor were carried out in both groups. On the basis of the above treatment, valsartan was added in the observation group. After 6 months of treatment, efficacy of the two groups as well as LVEF, LVMI, LVEDV, IVSD, LVPWD, LVEDD, and BNP levels before and after the treatment were compared. ResultsThe total effect rate of the observation group (95.6%) was higher than that of the control group (77.8%), which had significant difference (P＜0.05). After 6 months of treatment, level of LVEF increased and levels of LVMI, LVEDV, IVSD, LVPWD, and LVEDD decreased sharply in both groups compared with those before treatment, which had significant difference (P＜0.05). Level LVEF in the observation group was higher than that in the control group, while levels of LVMI, LVEDV, IVSD, LVPWD, and LVEDD were lower than those in the control group (P＜0.05 or P＜0.01) . BNP level in both groups was significantly lower compared with that before treatment (P＜0.05) . Compared with the control group, BNP level in the observation group decreased more sharply, and there was significant difference in BNP level between the two groups (P＜0.05) . ConclusionsValsartan combined with enalapril for chronic heart failure has distinct outcomes and can greatly improve cardiac function, which might be related to the decrease of BNP level. Further researches are expected to focus on the relation between them.

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