内科

目的探讨贝那普利联合拉西地平对高血压糖尿病患者早期肾损害的治疗效果。方法将高血压合并2型糖尿病并有微量白蛋白尿的患者159例随机分为三组，每组53例，A组给予贝那普利治疗，B组给予拉西地平治疗，C组给予贝那普利联合拉西地平治疗。观察三组患者治疗前后血压和肾功能的变化。结果治疗3个月后，三组患者血压均达标（≤130/80 mmHg）；治疗1年后，三组患者的微量白蛋白尿（MA）、胱抑素C（Cyt-C）及肌酐（Cr）均较治疗前下降，治疗前后比较，差异具有统计学意义（P均＜0.05），但联合用药的C组疗效更好。结论贝那普利、拉西地平对高血压糖尿病患者有明显降压作用及较好的降低尿微量白蛋白作用，两药合用可起到协同作用。

ObjectiveTo investigate the therapeutic effect of benazepril coupled with lacidipine on early renal damage in hypertensive patients with diabetes.Methods159 patients with hypertension complicated with type 2 diabetes and microalbuminuria were randomly divided into three groups with 53 cases in each.Patients in the group A and B were treated with benazepril and lacidipine respectively,while group C with benazepril and lacidipine.Blood pressure and renal function were observed before and after treatment.ResultsThe blood pressure in the three groups met the standard(≤130/80mmHg) in three months after the treatment.MA,Cyt-C and Cr in the three groups were dropped significantly after treatment (P＜0.05),while the therapeutic effect of group C is superior to the other two groups.ConclusionBoth benazepril and lacidipine have obvious antihypertensive effect and can reduce the microalbuminuria in hypertensive patients with diabetes.However,the combination of these two drugs shows a synergistic action.

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